CMV cell–mediated immunity assays: Focus on CD4 + cells

Cytotoxic CD4 T Cells in Antiviral Immunity

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in humans, mice, and other species in response to many diverse pathogens. Since CD4 cytotoxic T cells are able to recognize antigenic determinants unique from those recognized by the parallel CD8 cytotoxic T cells, they can potentially contribute additional immune surveillance and direct effector function ...

Cd4 T Cells in Infant Immunity

T-Cell Immunity Panel Measures CMV-Specific CD4 and CD8 T-Cell Responses

Chronic Viral Infections and Immunosenescence, with a Focus on CMV

The term immunosenescence is used to describe the decreased function of the immune system with age, and also to describe the phenotypic alterations in immune cells and cytokines that develop with age. The most dramatic phenotypic change is seen in the T cell compartment, where the percentage of cells with an effector memory phenotype increases, and the number and diversity of naïve cells decrea...

Levels of CMV Specific CD4 T Cells Are Dynamic and Correlate with CMV Viremia after Allogeneic Stem Cell Transplantation

Cytomegalovirus (CMV) infection is the most frequent viral complication in patients after allogeneic stem cell transplantation. As CMV replication is tightly controlled by the cellular arm of specific immunity, the kinetics of CMV-specific T cells in association with individual reactivation episodes were prospectively analyzed in 40 allogeneic transplant recipients in a routine clinical setting...